Primary characters

Yugi Mutou

Main article: Yugi Mutou
Yugi Mutou (武藤 遊戯 Mutō Yūgi, Yugi Muto in the English anime) is the protagonist of the first series. Yugi is especially adept at playing Duel Monsters. He wears the Millennium Puzzle, one of the seven Millennium Items and an ancient Egyptian artifact holding the spirit of the pharaoh around his neck. When Yugi is playing a game or under stress, the spirit inside the Millennium Puzzle surfaces and the 3,000-year-old (5,000 in the English anime) pharaoh, Yami (Dark) Yugi takes partial or complete control of the body.

Katsuya Jonouchi

Main article: Katsuya Jonouchi
Katsuya Jonouchi (城之内 克也 Jōnōchi Katsuya, Joey Wheeler in the English anime) is Yugi's best friend and the deuteragonist of the series. Initially nothing more than a street thug and former bully, Joey is touched by Yugi's behavior towards him and they become loyal friends. He likes playing games but usually loses to Yugi. Joey is rash and gets himself into trouble quite often.

] Seto Kaiba

Main article: Seto Kaiba
Seto Kaiba (海馬 瀬人 Kaiba Seto?) is the tritagonist of the series. He originally appeared as a mysterious guy, but later is seen as somewhat helping them. He believes that he is the best card duelist in the world, and that Yugi is just second rate. He does not believe in the magic of the Millennium Items in the English dub, but is a believer and a lot nicer in the Japanese show. Despite his age, he is the president of Kaiba Corporation, the biggest game company in the world and the most influential in the United States.

Anzu Mazaki

Main article: Anzu Mazaki
Anzu Mazaki (真崎 杏子 Mazaki Anzu, Téa Gardner in the English anime) is Yugi's childhood friend. Although her dueling ability is decent and she used to defeat Joey (before Solomon Muto tutored Joey), Téa is not a game-player and her ability is well below that of Yugi. She is sweet and supportive to everyone. She is athletic and secretly works at a fast food restaurant to save money; her dream is to attend dancing school in New York City.

Hiroto Honda

Hiroto Honda (本田 廣戶 Honda Hiroto, Tristan Taylor in the English anime) who is in class 1-B at Domino High School, is a boy who became a friend of Yugi Muto, Joey Wheeler, and Téa Gardner. In the manga, Honda starts out as Joey's street thug henchman and also at first has a crush on Melody Nosaka, who, however, rejects him. Tristan is also very intelligent, and a sharpshooter; Tristan says in the manga that when he was a kid, he could shoot a 100-yen piece with a BB gun from 50 feet. In the first series anime, Tristan is the head of the clean-up committee at school and often cites his duty while doing things, which causes him to annoy his friends. Tristan often argues with Joey. In Battle City, Tristan develops a crush on Joey's sister, Serenity Wheeler (Serenity Wheeler), and in the second series anime he fights with Ryuji Otogi (Duke Devlin) over her. Tristan uses a Military Deck, using Warriors and Machines related to the military theme. Prior to the duel with Rex Raptor, Joey discovers Tristan's cards, including a Lava Battleguard. Joey has a card called Swamp Battleguard, which works well with Lava Battleguard. Joey uses them in the duel against Ryuzaki, and they defeat Ryuzaki's second strongest dragon. Tristan uses his own strategy when he dueled against Nessbitt of the Big Five.
Honda is voiced by Ryotaro Okiayu in the first series. In Duel Monsters he is first voiced by Takayuki Kondo, then by Hidehiro Kikuchi from Episode 53 onwards. In the English dub, he is voiced by Sam Regal for the first ten episodes and Frank Frankson from episode 11 onwards.